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A genome is the collection of DNA that comprises an organism. Functional genomics is the genome-wide study of the function of DNA (including genes and nongenic elements), as well as the nucleic acid and protein products encoded by DNA.
Functional genomics may be applied to the complete collection of DNA (the genome), RNA (the transcriptome), or protein (the proteome) of an organism. The assessment of RNA transcripts that are expressed at various times of development or various body regions constitutes an example of functional genomics.
Functional genomics implies the use of high throughput screens, in contrast to traditional methods of biology in which one gene or protein has been characterized experimentally in depth. Such traditional methods commonly complement high throughput approaches. Functional genomics often involves the perturbation of gene function to investigate the consequence on the function of other genes in a genome.
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